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Monday 4 September 2017

What is ATP(Adenosine triphosphate)

Adenosine triphosphate (ATP)
 is a nucleotide used in cells as a coenzyme. It is often called the "molecular unit of currency": ATP transports chemical energy within cells for metabolism.
Every cell uses ATP for energy. It consists of a base (adenine) and three phosphate groups. One molecule of ATP contains three phosphate groups, and it is produced by ATP synthase from inorganic phosphate and adenosine diphosphate (ADP, the di meaning two phosphate groups) or adenosine monophosphate (AMP).


USAGE
The ATP molecule is very versatile, meaning that it can be used for many things. Energy is stored in its chemical bonds.
When ADP binds with another phosphate, energy is stored that can be used later. In other words, when a bond is made, energy is stored. This is an endothermic reaction.
When ATP breaks a bond with a phosphate group and becomes ADP, energy is released. In other words, when a bond is broken energy is released. This is an exothermic reaction. 
The ATP phosphate exchange is a nearly never-ending cycle, stopping only when the cell dies.


FUNCTIONS IN CELL
ATP is the main energy source for the majority of cellular functions. This includes the synthesis of macromolecules, including DNA and RNA (see below), and proteins. ATP also plays a critical role in the active transport of macromolecules across cell membranes, e.g. exocytosis and endocytosis.


DNA and RNA Synthesis
In all known organisms, the deoxyribonucleotides that make up DNA are synthesized by the action of ribonucleotide reductase (RNR) enzymes on their corresponding ribonucleotides.[1] These enzymes reduce the sugar residue from ribose to deoxyribose by removing oxygen.[1]
In the synthesis of the nucleic acid RNA, ATP is one of the four nucleotides incorporated directly into RNA molecules by RNA polymerases. The energy driving this polymerization comes from cleaving off a pyrophosphate (two phosphate groups).[2] The dance is similar in DNA biosynthesis, except that ATP is reduced to the deoxyribonucleotide dATP, before incorporation into DNA.


ATP first discovered in 1929


ATP was first discovered by the German chemist Karl Lohmann. Its structure is established some years later. In 1948 Alexander Todd (UK) synthesises ATP chemically.
Vladimir Engelhart (Russia) notes in 1935 that muscle contractions require ATP. Between 1939 and 1941 Fritz Lipmann (USA) shows that ATP is the main bearer of chemical energy in the cell. He coins the phrase "energy-rich phosphate bonds".

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